CTNNB1-IGF2BP2 Fusion FISH Probe
The CTNNB1-IGF2BP2 Fusion FISH Probe is used to confirm a fusion of the CTNNB1 and IGF2BP2 genes. The fusion of the CTNNB1 and IGF2BP2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNNB1-IGF2BP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-RERE | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-REOR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-REGO | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-REGR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-OROR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GORE | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GROR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNNB1-IGF2BP2-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNNB1 Gene Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Catenin Beta 1
Chromosome: CHR3: 41240941 -41281939
Locus: 3p22.1
IGF2BP2 Gene Summary
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Gene Name: Insulin Like Growth Factor 2 MRNA Binding Protein 2
Chromosome: CHR3: 185361526 -185542827
Locus: 3q27.2
Gene Diseases
The CTNNB1 IGF2BP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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