CTNNB1-TCOF1 Fusion FISH Probe
The CTNNB1-TCOF1 Fusion FISH Probe is used to confirm a fusion of the CTNNB1 and TCOF1 genes. The fusion of the CTNNB1 and TCOF1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNNB1-TCOF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-RERE | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-REOR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-REGO | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-REGR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-OROR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GORE | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GROR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNNB1-TCOF1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNNB1 Gene Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Catenin Beta 1
Chromosome: CHR3: 41240941 -41281939
Locus: 3p22.1
TCOF1 Gene Summary
This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: Treacle Ribosome Biogenesis Factor 1
Chromosome: CHR5: 149737201 -149779871
Locus: 5q32-q33.1
Gene Diseases
The CTNNB1 TCOF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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