CTNND2-POLR1A Fusion FISH Probe
The CTNND2-POLR1A Fusion FISH Probe is used to confirm a fusion of the CTNND2 and POLR1A genes. The fusion of the CTNND2 and POLR1A genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNND2-POLR1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-RERE | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-REOR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-REGO | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-REGR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-OROR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GORE | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GROR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNND2-POLR1A-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNND2 Gene Summary
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Name: Catenin Delta 2
Chromosome: CHR5: 10971951 -11904110
Locus: 5p15.2
POLR1A Gene Summary
The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]
Gene Name: RNA Polymerase I Subunit A
Chromosome: CHR2: 86253450 -86333278
Locus: 2p11.2
Gene Diseases
The CTNND2 POLR1A Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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