CTNND2-PPARGC1B Fusion FISH Probe
The CTNND2-PPARGC1B Fusion FISH Probe is used to confirm a fusion of the CTNND2 and PPARGC1B genes. The fusion of the CTNND2 and PPARGC1B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTNND2-PPARGC1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-RERE | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-REOR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-REGO | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-REGR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-REAQ | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-ORRE | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-OROR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-ORGO | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GORE | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GOOR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GOGO | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GOGR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GRRE | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GROR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GRGO | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GRGR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-AQRE | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-AQOR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-AQGO | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-AQGR | 20 (40 μL) | 200 μL |
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| CTNND2-PPARGC1B-20-AQAQ | 20 (40 μL) | 200 μL |
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CTNND2 Gene Summary
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Name: Catenin Delta 2
Chromosome: CHR5: 10971951 -11904110
Locus: 5p15.2
PPARGC1B Gene Summary
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Name: PPARG Coactivator 1 Beta
Chromosome: CHR5: 149109814 -149234585
Locus: 5q32
Gene Diseases
The CTNND2 PPARGC1B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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