CTPS2-RBBP7 Fusion FISH Probe
The CTPS2-RBBP7 Fusion FISH Probe is used to confirm a fusion of the CTPS2 and RBBP7 genes. The fusion of the CTPS2 and RBBP7 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTPS2-RBBP7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-RERE | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-REOR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-REGO | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-REGR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-REAQ | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-ORRE | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-OROR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-ORGO | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GORE | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GOOR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GOGO | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GOGR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GRRE | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GROR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GRGO | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GRGR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-AQRE | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-AQOR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-AQGO | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-AQGR | 20 (40 μL) | 200 μL |
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| CTPS2-RBBP7-20-AQAQ | 20 (40 μL) | 200 μL |
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RBBP7 Gene Summary
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: RB Binding Protein 7, Chromatin Remodeling Factor
Chromosome: CHRX: 16862774 -16888534
Locus: Xp22.2
CTPS2 Gene Summary
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: CTP Synthase 2
Chromosome: CHRX: 16606121 -16731059
Locus: Xp22.2
Gene Diseases
The CTPS2 RBBP7 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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