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CTSB-CBS Fusion FISH Probe

The CTSB-CBS Fusion FISH Probe is used to confirm a fusion of the CTSB and CBS genes. The fusion of the CTSB and CBS genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CTSB-CBS-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CTSB-CBS-20-RERE 20 (40 μL) 200 μL
CTSB-CBS-20-REOR 20 (40 μL) 200 μL
CTSB-CBS-20-REGO 20 (40 μL) 200 μL
CTSB-CBS-20-REGR 20 (40 μL) 200 μL
CTSB-CBS-20-REAQ 20 (40 μL) 200 μL
CTSB-CBS-20-ORRE 20 (40 μL) 200 μL
CTSB-CBS-20-OROR 20 (40 μL) 200 μL
CTSB-CBS-20-ORGO 20 (40 μL) 200 μL
CTSB-CBS-20-ORAQ 20 (40 μL) 200 μL
CTSB-CBS-20-GORE 20 (40 μL) 200 μL
CTSB-CBS-20-GOOR 20 (40 μL) 200 μL
CTSB-CBS-20-GOGO 20 (40 μL) 200 μL
CTSB-CBS-20-GOGR 20 (40 μL) 200 μL
CTSB-CBS-20-GOAQ 20 (40 μL) 200 μL
CTSB-CBS-20-GRRE 20 (40 μL) 200 μL
CTSB-CBS-20-GROR 20 (40 μL) 200 μL
CTSB-CBS-20-GRGO 20 (40 μL) 200 μL
CTSB-CBS-20-GRGR 20 (40 μL) 200 μL
CTSB-CBS-20-GRAQ 20 (40 μL) 200 μL
CTSB-CBS-20-AQRE 20 (40 μL) 200 μL
CTSB-CBS-20-AQOR 20 (40 μL) 200 μL
CTSB-CBS-20-AQGO 20 (40 μL) 200 μL
CTSB-CBS-20-AQGR 20 (40 μL) 200 μL
CTSB-CBS-20-AQAQ 20 (40 μL) 200 μL

CBS Gene Summary

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

Gene Name: Cystathionine-beta-synthase

Chromosome: CHR21: 44473300 -44496472

Locus: 21q22.3

CTSB Gene Summary

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

Gene Name: Cathepsin B

Chromosome: CHR8: 11700033 -11725646

Locus: 8p23.1

Gene Diseases

The CTSB CBS Fusion has been associated with the following diseases:

Disease Name
Thyroid Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.