CTSB-EIF4A2 Fusion FISH Probe
The CTSB-EIF4A2 Fusion FISH Probe is used to confirm a fusion of the CTSB and EIF4A2 genes. The fusion of the CTSB and EIF4A2 genes has been associated with Thyroid Carcinoma, Thyroid Carcinoma, and Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSB-EIF4A2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-RERE | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-REOR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-REGO | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-REGR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-OROR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GORE | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GROR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSB-EIF4A2-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSB Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033 -11725646
Locus: 8p23.1
EIF4A2 Gene Summary
The Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) gene is located on chr3 :186501360-186507685 at 3q27.3.
Gene Name: Eukaryotic Translation Initiation Factor 4A2
Chromosome: CHR3: 186501360 -186507685
Locus: 3q27.3
Gene Diseases
The CTSB EIF4A2 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
| Thyroid Carcinoma |
| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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