CTSB-FAR1 Fusion FISH Probe
The CTSB-FAR1 Fusion FISH Probe is used to confirm a fusion of the CTSB and FAR1 genes. The fusion of the CTSB and FAR1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSB-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSB-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSB Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033 -11725646
Locus: 8p23.1
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The CTSB FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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