CTSB-TMEM173 Fusion FISH Probe
The CTSB-TMEM173 Fusion FISH Probe is used to confirm a fusion of the CTSB and TMEM173 genes. The fusion of the CTSB and TMEM173 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTSB-TMEM173-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-RERE | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-REOR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-REGO | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-REGR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-REAQ | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-ORRE | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-OROR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-ORGO | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GORE | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GOOR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GOGO | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GOGR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GRRE | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GROR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GRGO | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GRGR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-AQRE | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-AQOR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-AQGO | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-AQGR | 20 (40 μL) | 200 μL |
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| CTSB-TMEM173-20-AQAQ | 20 (40 μL) | 200 μL |
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CTSB Gene Summary
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]
Gene Name: Cathepsin B
Chromosome: CHR8: 11700033 -11725646
Locus: 8p23.1
TMEM173 Gene Summary
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Name: Transmembrane Protein 173
Chromosome: CHR5: 138855112 -138862343
Locus: 5q31.2
Gene Diseases
The CTSB TMEM173 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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