CTTN-FOLR1 Fusion FISH Probe
The CTTN-FOLR1 Fusion FISH Probe is used to confirm a fusion of the CTTN and FOLR1 genes. The fusion of the CTTN and FOLR1 genes has been associated with Brain Lower Grade Glioma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CTTN-FOLR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-RERE | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-REOR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-REGO | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-REGR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-REAQ | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-ORRE | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-OROR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-ORGO | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GORE | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GOOR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GOGO | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GOGR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GRRE | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GROR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GRGO | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GRGR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-AQRE | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-AQOR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-AQGO | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-AQGR | 20 (40 μL) | 200 μL |
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| CTTN-FOLR1-20-AQAQ | 20 (40 μL) | 200 μL |
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CTTN Gene Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Name: Cortactin
Chromosome: CHR11: 70244611 -70282690
Locus: 11q13.3
FOLR1 Gene Summary
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Folate Receptor 1
Chromosome: CHR11: 71900601 -71907367
Locus: 11q13.4
Gene Diseases
The CTTN FOLR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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