CXCL14-C7 Fusion FISH Probe
The CXCL14-C7 Fusion FISH Probe is used to confirm a fusion of the CXCL14 and C7 genes. The fusion of the CXCL14 and C7 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CXCL14-C7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-RERE | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-REOR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-REGO | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-REGR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-REAQ | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-ORRE | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-OROR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-ORGO | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-ORAQ | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GORE | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GOOR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GOGO | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GOGR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GOAQ | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GRRE | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GROR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GRGO | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GRGR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-GRAQ | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-AQRE | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-AQOR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-AQGO | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-AQGR | 20 (40 μL) | 200 μL |
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| CXCL14-C7-20-AQAQ | 20 (40 μL) | 200 μL |
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C7 Gene Summary
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Gene Name: Complement C7
Chromosome: CHR5: 40909598 -40983042
Locus: 5p13.1
CXCL14 Gene Summary
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]
Gene Name: C-X-C Motif Chemokine Ligand 14
Chromosome: CHR5: 134906370 -134914969
Locus: 5q31.1
Gene Diseases
The CXCL14 C7 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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