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CYP7B1-SULF1 Fusion FISH Probe

The CYP7B1-SULF1 Fusion FISH Probe is used to confirm a fusion of the CYP7B1 and SULF1 genes. The fusion of the CYP7B1 and SULF1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
CYP7B1-SULF1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
CYP7B1-SULF1-20-RERE 20 (40 μL) 200 μL
CYP7B1-SULF1-20-REOR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-REGO 20 (40 μL) 200 μL
CYP7B1-SULF1-20-REGR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-REAQ 20 (40 μL) 200 μL
CYP7B1-SULF1-20-ORRE 20 (40 μL) 200 μL
CYP7B1-SULF1-20-OROR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-ORGO 20 (40 μL) 200 μL
CYP7B1-SULF1-20-ORAQ 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GORE 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GOOR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GOGO 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GOGR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GOAQ 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GRRE 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GROR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GRGO 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GRGR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-GRAQ 20 (40 μL) 200 μL
CYP7B1-SULF1-20-AQRE 20 (40 μL) 200 μL
CYP7B1-SULF1-20-AQOR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-AQGO 20 (40 μL) 200 μL
CYP7B1-SULF1-20-AQGR 20 (40 μL) 200 μL
CYP7B1-SULF1-20-AQAQ 20 (40 μL) 200 μL

CYP7B1 Gene Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]

Gene Name: Cytochrome P450 Family 7 Subfamily B Member 1

Chromosome: CHR8: 65508528 -65711348

Locus: 8q12.3

SULF1 Gene Summary

This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Name: Sulfatase 1

Chromosome: CHR8: 70378858 -70573147

Locus: 8q13.2-q13.3

Gene Diseases

The CYP7B1 SULF1 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.