DAAM1-PRKCH Fusion FISH Probe
The DAAM1-PRKCH Fusion FISH Probe is used to confirm a fusion of the DAAM1 and PRKCH genes. The fusion of the DAAM1 and PRKCH genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DAAM1-PRKCH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-RERE | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-REOR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-REGO | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-REGR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-REAQ | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-ORRE | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-OROR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-ORGO | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-ORAQ | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GORE | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GOOR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GOGO | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GOGR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GOAQ | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GRRE | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GROR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GRGO | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GRGR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-GRAQ | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-AQRE | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-AQOR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-AQGO | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-AQGR | 20 (40 μL) | 200 μL |
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| DAAM1-PRKCH-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCH Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]
Gene Name: Protein Kinase C Eta
Chromosome: CHR14: 61788514 -62017698
Locus: 14q23.1
DAAM1 Gene Summary
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Gene Name: Dishevelled Associated Activator Of Morphogenesis 1
Chromosome: CHR14: 59655398 -59836471
Locus: 14q23.1
Gene Diseases
The DAAM1 PRKCH Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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