DAB2-COL4A3BP Fusion FISH Probe
The DAB2-COL4A3BP Fusion FISH Probe is used to confirm a fusion of the DAB2 and COL4A3BP genes. The fusion of the DAB2 and COL4A3BP genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DAB2-COL4A3BP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-RERE | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-REOR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-REGO | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-REGR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-REAQ | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-ORRE | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-OROR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-ORGO | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-ORAQ | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GORE | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GOOR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GOGO | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GOGR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GOAQ | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GRRE | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GROR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GRGO | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GRGR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-GRAQ | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-AQRE | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-AQOR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-AQGO | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-AQGR | 20 (40 μL) | 200 μL |
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| DAB2-COL4A3BP-20-AQAQ | 20 (40 μL) | 200 μL |
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DAB2 Gene Summary
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: DAB2, Clathrin Adaptor Protein
Chromosome: CHR5: 39371779 -39425335
Locus: 5p13.1
COL4A3BP Gene Summary
This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Collagen Type IV Alpha 3 Binding Protein
Chromosome: CHR5: 74666927 -74807806
Locus: 5q13.3
Gene Diseases
The DAB2 COL4A3BP Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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