DACH1-KLF12 Fusion FISH Probe
The DACH1-KLF12 Fusion FISH Probe is used to confirm a fusion of the DACH1 and KLF12 genes. The fusion of the DACH1 and KLF12 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DACH1-KLF12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-RERE | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-REOR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-REGO | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-REGR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-REAQ | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-ORRE | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-OROR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-ORGO | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-ORAQ | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GORE | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GOOR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GOGO | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GOGR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GOAQ | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GRRE | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GROR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GRGO | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GRGR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-GRAQ | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-AQRE | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-AQOR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-AQGO | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-AQGR | 20 (40 μL) | 200 μL |
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| DACH1-KLF12-20-AQAQ | 20 (40 μL) | 200 μL |
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DACH1 Gene Summary
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Dachshund Family Transcription Factor 1
Chromosome: CHR13: 72012097 -72441330
Locus: 13q21.33
KLF12 Gene Summary
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Kruppel Like Factor 12
Chromosome: CHR13: 74260148 -74708066
Locus: 13q22.1
Gene Diseases
The DACH1 KLF12 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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