DARS-MGAT5 Fusion FISH Probe
The DARS-MGAT5 Fusion FISH Probe is used to confirm a fusion of the DARS and MGAT5 genes. The fusion of the DARS and MGAT5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DARS-MGAT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-RERE | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-REOR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-REGO | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-REGR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-REAQ | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-ORRE | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-OROR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-ORGO | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GORE | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GOOR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GOGO | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GOGR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GRRE | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GROR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GRGO | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GRGR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-AQRE | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-AQOR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-AQGO | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-AQGR | 20 (40 μL) | 200 μL |
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| DARS-MGAT5-20-AQAQ | 20 (40 μL) | 200 μL |
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DARS Gene Summary
This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Aspartyl-tRNA Synthetase
Chromosome: CHR2: 136664253 -136743222
Locus: 2q21.3
MGAT5 Gene Summary
The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]
Gene Name: Mannosyl (alpha-1,6-)-glycoprotein Beta-1,6-N-acetyl-glucosaminyltransferase
Chromosome: CHR2: 135011829 -135206468
Locus: 2q21.2-q21.3
Gene Diseases
The DARS MGAT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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