DCLK2-LRBA Fusion FISH Probe
The DCLK2-LRBA Fusion FISH Probe is used to confirm a fusion of the DCLK2 and LRBA genes. The fusion of the DCLK2 and LRBA genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCLK2-LRBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-RERE | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-REOR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-REGO | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-REGR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-REAQ | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-ORRE | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-OROR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-ORGO | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GORE | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GOOR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GOGO | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GOGR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GRRE | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GROR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GRGO | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GRGR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-AQRE | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-AQOR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-AQGO | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-AQGR | 20 (40 μL) | 200 μL |
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| DCLK2-LRBA-20-AQAQ | 20 (40 μL) | 200 μL |
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LRBA Gene Summary
The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: LPS Responsive Beige-like Anchor Protein
Chromosome: CHR4: 151185810 -151936649
Locus: 4q31.3
DCLK2 Gene Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
Gene Name: Doublecortin Like Kinase 2
Chromosome: CHR4: 150999425 -151178608
Locus: 4q31.23-q31.3
Gene Diseases
The DCLK2 LRBA Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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