DCLK2-UST Fusion FISH Probe
The DCLK2-UST Fusion FISH Probe is used to confirm a fusion of the DCLK2 and UST genes. The fusion of the DCLK2 and UST genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCLK2-UST-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-RERE | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-REOR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-REGO | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-REGR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-REAQ | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-ORRE | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-OROR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-ORGO | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GORE | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GOOR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GOGO | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GOGR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GRRE | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GROR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GRGO | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GRGR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-AQRE | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-AQOR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-AQGO | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-AQGR | 20 (40 μL) | 200 μL |
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| DCLK2-UST-20-AQAQ | 20 (40 μL) | 200 μL |
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UST Gene Summary
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Gene Name: Uronyl 2-sulfotransferase
Chromosome: CHR6: 149068270 -149398126
Locus: 6q25.1
DCLK2 Gene Summary
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
Gene Name: Doublecortin Like Kinase 2
Chromosome: CHR4: 150999425 -151178608
Locus: 4q31.23-q31.3
Gene Diseases
The DCLK2 UST Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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