DCLRE1B-DNAJB4 Fusion FISH Probe
The DCLRE1B-DNAJB4 Fusion FISH Probe is used to confirm a fusion of the DCLRE1B and DNAJB4 genes. The fusion of the DCLRE1B and DNAJB4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCLRE1B-DNAJB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-RERE | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-REOR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-REGO | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-REGR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-REAQ | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-ORRE | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-OROR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-ORGO | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GORE | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GOOR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GOGO | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GOGR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GRRE | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GROR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GRGO | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GRGR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-AQRE | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-AQOR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-AQGO | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-AQGR | 20 (40 μL) | 200 μL |
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| DCLRE1B-DNAJB4-20-AQAQ | 20 (40 μL) | 200 μL |
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DNAJB4 Gene Summary
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member B4
Chromosome: CHR1: 78470635 -78482995
Locus: 1p31.1
DCLRE1B Gene Summary
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]
Gene Name: DNA Cross-link Repair 1B
Chromosome: CHR1: 114447914 -114456708
Locus: 1p13.2
Gene Diseases
The DCLRE1B DNAJB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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