DCTN1-WDR54 Fusion FISH Probe
The DCTN1-WDR54 Fusion FISH Probe is used to confirm a fusion of the DCTN1 and WDR54 genes. The fusion of the DCTN1 and WDR54 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DCTN1-WDR54-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-RERE | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-REOR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-REGO | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-REGR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-REAQ | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-ORRE | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-OROR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-ORGO | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-ORAQ | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GORE | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GOOR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GOGO | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GOGR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GOAQ | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GRRE | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GROR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GRGO | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GRGR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-GRAQ | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-AQRE | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-AQOR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-AQGO | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-AQGR | 20 (40 μL) | 200 μL |
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| DCTN1-WDR54-20-AQAQ | 20 (40 μL) | 200 μL |
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DCTN1 Gene Summary
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
Gene Name: Dynactin Subunit 1
Chromosome: CHR2: 74588280 -74619214
Locus: 2p13.1
WDR54 Gene Summary
The WD Repeat Domain 54 (WDR54) gene is located on chr2 :74648884-74652882 at 2p13.1.
Gene Name: WD Repeat Domain 54
Chromosome: CHR2: 74648884 -74652882
Locus: 2p13.1
Gene Diseases
The DCTN1 WDR54 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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