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DCTN2-DDX23 Fusion FISH Probe

The DCTN2-DDX23 Fusion FISH Probe is used to confirm a fusion of the DCTN2 and DDX23 genes. The fusion of the DCTN2 and DDX23 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DCTN2-DDX23-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DCTN2-DDX23-20-RERE 20 (40 μL) 200 μL
DCTN2-DDX23-20-REOR 20 (40 μL) 200 μL
DCTN2-DDX23-20-REGO 20 (40 μL) 200 μL
DCTN2-DDX23-20-REGR 20 (40 μL) 200 μL
DCTN2-DDX23-20-REAQ 20 (40 μL) 200 μL
DCTN2-DDX23-20-ORRE 20 (40 μL) 200 μL
DCTN2-DDX23-20-OROR 20 (40 μL) 200 μL
DCTN2-DDX23-20-ORGO 20 (40 μL) 200 μL
DCTN2-DDX23-20-ORAQ 20 (40 μL) 200 μL
DCTN2-DDX23-20-GORE 20 (40 μL) 200 μL
DCTN2-DDX23-20-GOOR 20 (40 μL) 200 μL
DCTN2-DDX23-20-GOGO 20 (40 μL) 200 μL
DCTN2-DDX23-20-GOGR 20 (40 μL) 200 μL
DCTN2-DDX23-20-GOAQ 20 (40 μL) 200 μL
DCTN2-DDX23-20-GRRE 20 (40 μL) 200 μL
DCTN2-DDX23-20-GROR 20 (40 μL) 200 μL
DCTN2-DDX23-20-GRGO 20 (40 μL) 200 μL
DCTN2-DDX23-20-GRGR 20 (40 μL) 200 μL
DCTN2-DDX23-20-GRAQ 20 (40 μL) 200 μL
DCTN2-DDX23-20-AQRE 20 (40 μL) 200 μL
DCTN2-DDX23-20-AQOR 20 (40 μL) 200 μL
DCTN2-DDX23-20-AQGO 20 (40 μL) 200 μL
DCTN2-DDX23-20-AQGR 20 (40 μL) 200 μL
DCTN2-DDX23-20-AQAQ 20 (40 μL) 200 μL

DDX23 Gene Summary

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Gene Name: DEAD-box Helicase 23

Chromosome: CHR12: 49223538 -49245957

Locus: 12q13.12

DCTN2 Gene Summary

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Name: Dynactin Subunit 2

Chromosome: CHR12: 57924093 -57940978

Locus: 12q13.3

Gene Diseases

The DCTN2 DDX23 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.