DDB1-SDHA Fusion FISH Probe
The DDB1-SDHA Fusion FISH Probe is used to confirm a fusion of the DDB1 and SDHA genes. The fusion of the DDB1 and SDHA genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDB1-SDHA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-RERE | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-REOR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-REGO | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-REGR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-REAQ | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-ORRE | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-OROR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-ORGO | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GORE | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GOOR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GOGO | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GOGR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GRRE | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GROR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GRGO | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GRGR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-AQRE | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-AQOR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-AQGO | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-AQGR | 20 (40 μL) | 200 μL |
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| DDB1-SDHA-20-AQAQ | 20 (40 μL) | 200 μL |
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DDB1 Gene Summary
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
Gene Name: Damage Specific DNA Binding Protein 1
Chromosome: CHR11: 61066918 -61100666
Locus: 11q12.2
SDHA Gene Summary
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Name: Succinate Dehydrogenase Complex Flavoprotein Subunit A
Chromosome: CHR5: 218355 -256814
Locus: 5p15.33
Gene Diseases
The DDB1 SDHA Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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