DDR1-PAK1 Fusion FISH Probe
The DDR1-PAK1 Fusion FISH Probe is used to confirm a fusion of the DDR1 and PAK1 genes. The fusion of the DDR1 and PAK1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDR1-PAK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-RERE | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-REOR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-REGO | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-REGR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-REAQ | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-ORRE | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-OROR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-ORGO | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GORE | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GOOR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GOGO | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GOGR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GRRE | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GROR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GRGO | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GRGR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-AQRE | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-AQOR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-AQGO | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-AQGR | 20 (40 μL) | 200 μL |
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| DDR1-PAK1-20-AQAQ | 20 (40 μL) | 200 μL |
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DDR1 Gene Summary
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Gene Name: Discoidin Domain Receptor Tyrosine Kinase 1
Chromosome: CHR6_dbb_hap3: 2145962 -2162051
Locus: 6p21.33
PAK1 Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: P21 (RAC1) Activated Kinase 1
Chromosome: CHR11: 77033059 -77185108
Locus: 11q13.5-q14.1
Gene Diseases
The DDR1 PAK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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