DDR2-CHD1L Fusion FISH Probe
The DDR2-CHD1L Fusion FISH Probe is used to confirm a fusion of the DDR2 and CHD1L genes. The fusion of the DDR2 and CHD1L genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDR2-CHD1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-RERE | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-REOR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-REGO | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-REGR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-REAQ | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-ORRE | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-OROR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-ORGO | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GORE | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GOOR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GOGO | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GOGR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GRRE | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GROR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GRGO | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GRGR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-AQRE | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-AQOR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-AQGO | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-AQGR | 20 (40 μL) | 200 μL |
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| DDR2-CHD1L-20-AQAQ | 20 (40 μL) | 200 μL |
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DDR2 Gene Summary
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]
Gene Name: Discoidin Domain Receptor Tyrosine Kinase 2
Chromosome: CHR1: 162602227 -162750247
Locus: 1q23.3
CHD1L Gene Summary
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
Gene Name: Chromodomain Helicase DNA Binding Protein 1 Like
Chromosome: CHR1: 146714290 -146767443
Locus: 1q21.1
Gene Diseases
The DDR2 CHD1L Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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