DDR2-FMO4 Fusion FISH Probe
The DDR2-FMO4 Fusion FISH Probe is used to confirm a fusion of the DDR2 and FMO4 genes. The fusion of the DDR2 and FMO4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDR2-FMO4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-RERE | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-REOR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-REGO | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-REGR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-REAQ | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-ORRE | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-OROR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-ORGO | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GORE | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GOOR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GOGO | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GOGR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GRRE | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GROR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GRGO | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GRGR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-AQRE | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-AQOR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-AQGO | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-AQGR | 20 (40 μL) | 200 μL |
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| DDR2-FMO4-20-AQAQ | 20 (40 μL) | 200 μL |
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FMO4 Gene Summary
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
Gene Name: Flavin Containing Monooxygenase 4
Chromosome: CHR1: 171283485 -171311223
Locus: 1q24.3
DDR2 Gene Summary
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia. [provided by RefSeq, Aug 2017]
Gene Name: Discoidin Domain Receptor Tyrosine Kinase 2
Chromosome: CHR1: 162602227 -162750247
Locus: 1q23.3
Gene Diseases
The DDR2 FMO4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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