DDX47-CREBL2 Fusion FISH Probe
The DDX47-CREBL2 Fusion FISH Probe is used to confirm a fusion of the DDX47 and CREBL2 genes. The fusion of the DDX47 and CREBL2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDX47-CREBL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-RERE | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-REOR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-REGO | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-REGR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-REAQ | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-ORRE | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-OROR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-ORGO | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GORE | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GOOR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GOGO | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GOGR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GRRE | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GROR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GRGO | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GRGR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-AQRE | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-AQOR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-AQGO | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-AQGR | 20 (40 μL) | 200 μL |
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| DDX47-CREBL2-20-AQAQ | 20 (40 μL) | 200 μL |
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CREBL2 Gene Summary
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Name: CAMP Responsive Element Binding Protein Like 2
Chromosome: CHR12: 12764830 -12798041
Locus: 12p13.1
DDX47 Gene Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 47
Chromosome: CHR12: 12966279 -12982915
Locus: 12p13.1
Gene Diseases
The DDX47 CREBL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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