DDX6-ALK Fusion FISH Probe
The DDX6-ALK Fusion FISH Probe is used to confirm a fusion of the DDX6 and ALK genes. The fusion of the DDX6 and ALK genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DDX6-ALK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-RERE | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-REOR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-REGO | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-REGR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-REAQ | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-ORRE | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-OROR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-ORGO | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-ORAQ | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GORE | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GOOR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GOGO | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GOGR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GOAQ | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GRRE | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GROR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GRGO | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GRGR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-GRAQ | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-AQRE | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-AQOR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-AQGO | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-AQGR | 20 (40 μL) | 200 μL |
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| DDX6-ALK-20-AQAQ | 20 (40 μL) | 200 μL |
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ALK Gene Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Gene Name: ALK Receptor Tyrosine Kinase
Chromosome: CHR2: 29415639 -30144477
Locus: 2p23.2-p23.1
DDX6 Gene Summary
This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
Gene Name: DEAD-box Helicase 6
Chromosome: CHR11: 118618472 -118661972
Locus: 11q23.3
Gene Diseases
The DDX6 ALK Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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