DENND1A-NDUFA8 Fusion FISH Probe
The DENND1A-NDUFA8 Fusion FISH Probe is used to confirm a fusion of the DENND1A and NDUFA8 genes. The fusion of the DENND1A and NDUFA8 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DENND1A-NDUFA8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-RERE | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-REOR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-REGO | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-REGR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-OROR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GORE | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GROR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| DENND1A-NDUFA8-20-AQAQ | 20 (40 μL) | 200 μL |
|
NDUFA8 Gene Summary
The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: NADH:ubiquinone Oxidoreductase Subunit A8
Chromosome: CHR9: 124906337 -124922098
Locus: 9q33.2
DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
Gene Diseases
The DENND1A NDUFA8 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|