DENND1A-SCUBE1 Fusion FISH Probe
The DENND1A-SCUBE1 Fusion FISH Probe is used to confirm a fusion of the DENND1A and SCUBE1 genes. The fusion of the DENND1A and SCUBE1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND1A-SCUBE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-RERE | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-REOR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-REGO | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-REGR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-OROR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GORE | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GROR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND1A-SCUBE1-20-AQAQ | 20 (40 μL) | 200 μL |
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DENND1A Gene Summary
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Name: DENN Domain Containing 1A
Chromosome: CHR9: 126141932 -126692417
Locus: 9q33.3
SCUBE1 Gene Summary
This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]
Gene Name: Signal Peptide, CUB Domain And EGF Like Domain Containing 1
Chromosome: CHR22: 43599228 -43739394
Locus: 22q13.2
Gene Diseases
The DENND1A SCUBE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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