DENND5B-PLCZ1 Fusion FISH Probe
The DENND5B-PLCZ1 Fusion FISH Probe is used to confirm a fusion of the DENND5B and PLCZ1 genes. The fusion of the DENND5B and PLCZ1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DENND5B-PLCZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-RERE | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-REOR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-REGO | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-REGR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-OROR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GORE | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GROR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| DENND5B-PLCZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLCZ1 Gene Summary
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: Phospholipase C Zeta 1
Chromosome: CHR12: 18836115 -18890918
Locus: 12p12.3
DENND5B Gene Summary
The DENN Domain Containing 5B (DENND5B) gene is located on chr12 :31535156-31743952 at 12p11.21.
Gene Name: DENN Domain Containing 5B
Chromosome: CHR12: 31535156 -31743952
Locus: 12p11.21
Gene Diseases
The DENND5B PLCZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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