DEPDC5-BID Fusion FISH Probe
The DEPDC5-BID Fusion FISH Probe is used to confirm a fusion of the DEPDC5 and BID genes. The fusion of the DEPDC5 and BID genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DEPDC5-BID-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-RERE | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-REOR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-REGO | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-REGR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-REAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-ORRE | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-OROR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-ORGO | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-ORAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GORE | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GOOR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GOGO | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GOGR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GOAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GRRE | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GROR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GRGO | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GRGR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-GRAQ | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-AQRE | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-AQOR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-AQGO | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-AQGR | 20 (40 μL) | 200 μL |
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| DEPDC5-BID-20-AQAQ | 20 (40 μL) | 200 μL |
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BID Gene Summary
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Gene Name: BH3 Interacting Domain Death Agonist
Chromosome: CHR22: 18216905 -18257258
Locus: 22q11.21
DEPDC5 Gene Summary
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Name: DEP Domain Containing 5
Chromosome: CHR22: 32149936 -32303020
Locus: 22q12.2-q12.3
Gene Diseases
The DEPDC5 BID Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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