DGKD-SAG Fusion FISH Probe
The DGKD-SAG Fusion FISH Probe is used to confirm a fusion of the DGKD and SAG genes. The fusion of the DGKD and SAG genes has been associated with Lung Adenocarcinoma, Esophageal Carcinoma, and Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGKD-SAG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-RERE | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-REOR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-REGO | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-REGR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-REAQ | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-ORRE | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-OROR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-ORGO | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GORE | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GOOR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GOGO | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GOGR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GRRE | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GROR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GRGO | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GRGR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-AQRE | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-AQOR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-AQGO | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-AQGR | 20 (40 μL) | 200 μL |
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| DGKD-SAG-20-AQAQ | 20 (40 μL) | 200 μL |
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SAG Gene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]
Gene Name: S-antigen Visual Arrestin
Chromosome: CHR2: 234216308 -234255701
Locus: 2q37.1
DGKD Gene Summary
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Diacylglycerol Kinase Delta
Chromosome: CHR2: 234263152 -234380743
Locus: 2q37.1
Gene Diseases
The DGKD SAG Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Esophageal Carcinoma |
| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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