DGKG-CRYGS Fusion FISH Probe
The DGKG-CRYGS Fusion FISH Probe is used to confirm a fusion of the DGKG and CRYGS genes. The fusion of the DGKG and CRYGS genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DGKG-CRYGS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-RERE | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-REOR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-REGO | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-REGR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-REAQ | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-ORRE | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-OROR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-ORGO | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-ORAQ | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GORE | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GOOR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GOGO | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GOGR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GOAQ | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GRRE | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GROR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GRGO | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GRGR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-GRAQ | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-AQRE | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-AQOR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-AQGO | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-AQGR | 20 (40 μL) | 200 μL |
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| DGKG-CRYGS-20-AQAQ | 20 (40 μL) | 200 μL |
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CRYGS Gene Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]
Gene Name: Crystallin Gamma S
Chromosome: CHR3: 186256231 -186262167
Locus: 3q27.3
DGKG Gene Summary
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Diacylglycerol Kinase Gamma
Chromosome: CHR3: 185864989 -186080023
Locus: 3q27.2-q27.3
Gene Diseases
The DGKG CRYGS Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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