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DNM2-MRPL4 Fusion FISH Probe

The DNM2-MRPL4 Fusion FISH Probe is used to confirm a fusion of the DNM2 and MRPL4 genes. The fusion of the DNM2 and MRPL4 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
DNM2-MRPL4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
DNM2-MRPL4-20-RERE 20 (40 μL) 200 μL
DNM2-MRPL4-20-REOR 20 (40 μL) 200 μL
DNM2-MRPL4-20-REGO 20 (40 μL) 200 μL
DNM2-MRPL4-20-REGR 20 (40 μL) 200 μL
DNM2-MRPL4-20-REAQ 20 (40 μL) 200 μL
DNM2-MRPL4-20-ORRE 20 (40 μL) 200 μL
DNM2-MRPL4-20-OROR 20 (40 μL) 200 μL
DNM2-MRPL4-20-ORGO 20 (40 μL) 200 μL
DNM2-MRPL4-20-ORAQ 20 (40 μL) 200 μL
DNM2-MRPL4-20-GORE 20 (40 μL) 200 μL
DNM2-MRPL4-20-GOOR 20 (40 μL) 200 μL
DNM2-MRPL4-20-GOGO 20 (40 μL) 200 μL
DNM2-MRPL4-20-GOGR 20 (40 μL) 200 μL
DNM2-MRPL4-20-GOAQ 20 (40 μL) 200 μL
DNM2-MRPL4-20-GRRE 20 (40 μL) 200 μL
DNM2-MRPL4-20-GROR 20 (40 μL) 200 μL
DNM2-MRPL4-20-GRGO 20 (40 μL) 200 μL
DNM2-MRPL4-20-GRGR 20 (40 μL) 200 μL
DNM2-MRPL4-20-GRAQ 20 (40 μL) 200 μL
DNM2-MRPL4-20-AQRE 20 (40 μL) 200 μL
DNM2-MRPL4-20-AQOR 20 (40 μL) 200 μL
DNM2-MRPL4-20-AQGO 20 (40 μL) 200 μL
DNM2-MRPL4-20-AQGR 20 (40 μL) 200 μL
DNM2-MRPL4-20-AQAQ 20 (40 μL) 200 μL

DNM2 Gene Summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Gene Name: Dynamin 2

Chromosome: CHR19: 10828728 -10942586

Locus: 19p13.2

MRPL4 Gene Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

Gene Name: Mitochondrial Ribosomal Protein L4

Chromosome: CHR19: 10362639 -10370736

Locus: 19p13.2

Gene Diseases

The DNM2 MRPL4 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.