DST-AKAP6 Fusion FISH Probe
The DST-AKAP6 Fusion FISH Probe is used to confirm a fusion of the DST and AKAP6 genes. The fusion of the DST and AKAP6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DST-AKAP6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-RERE | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-REOR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-REGO | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-REGR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-REAQ | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-ORRE | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-OROR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-ORGO | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-ORAQ | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GORE | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GOOR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GOGO | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GOGR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GOAQ | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GRRE | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GROR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GRGO | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GRGR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-GRAQ | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-AQRE | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-AQOR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-AQGO | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-AQGR | 20 (40 μL) | 200 μL |
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| DST-AKAP6-20-AQAQ | 20 (40 μL) | 200 μL |
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DST Gene Summary
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Name: Dystonin
Chromosome: CHR6: 56322784 -56507694
Locus: 6p12.1
AKAP6 Gene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008]
Gene Name: A-kinase Anchoring Protein 6
Chromosome: CHR14: 32798478 -33302268
Locus: 14q12
Gene Diseases
The DST AKAP6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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