DST-FBLN5 Fusion FISH Probe
The DST-FBLN5 Fusion FISH Probe is used to confirm a fusion of the DST and FBLN5 genes. The fusion of the DST and FBLN5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DST-FBLN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-RERE | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-REOR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-REGO | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-REGR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-REAQ | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-ORRE | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-OROR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-ORGO | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GORE | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GOOR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GOGO | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GOGR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GRRE | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GROR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GRGO | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GRGR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-AQRE | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-AQOR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-AQGO | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-AQGR | 20 (40 μL) | 200 μL |
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| DST-FBLN5-20-AQAQ | 20 (40 μL) | 200 μL |
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DST Gene Summary
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Name: Dystonin
Chromosome: CHR6: 56322784 -56507694
Locus: 6p12.1
FBLN5 Gene Summary
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Gene Name: Fibulin 5
Chromosome: CHR14: 92335754 -92414046
Locus: 14q32.12
Gene Diseases
The DST FBLN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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