DST-HCST Fusion FISH Probe
The DST-HCST Fusion FISH Probe is used to confirm a fusion of the DST and HCST genes. The fusion of the DST and HCST genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DST-HCST-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DST-HCST-20-RERE | 20 (40 μL) | 200 μL |
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| DST-HCST-20-REOR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-REGO | 20 (40 μL) | 200 μL |
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| DST-HCST-20-REGR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-REAQ | 20 (40 μL) | 200 μL |
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| DST-HCST-20-ORRE | 20 (40 μL) | 200 μL |
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| DST-HCST-20-OROR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-ORGO | 20 (40 μL) | 200 μL |
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| DST-HCST-20-ORAQ | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GORE | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GOOR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GOGO | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GOGR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GOAQ | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GRRE | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GROR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GRGO | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GRGR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-GRAQ | 20 (40 μL) | 200 μL |
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| DST-HCST-20-AQRE | 20 (40 μL) | 200 μL |
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| DST-HCST-20-AQOR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-AQGO | 20 (40 μL) | 200 μL |
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| DST-HCST-20-AQGR | 20 (40 μL) | 200 μL |
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| DST-HCST-20-AQAQ | 20 (40 μL) | 200 μL |
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DST Gene Summary
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Name: Dystonin
Chromosome: CHR6: 56322784 -56507694
Locus: 6p12.1
HCST Gene Summary
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Hematopoietic Cell Signal Transducer
Chromosome: CHR19: 36393381 -36395173
Locus: 19q13.12
Gene Diseases
The DST HCST Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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