DTNB-ASXL2 Fusion FISH Probe
The DTNB-ASXL2 Fusion FISH Probe is used to confirm a fusion of the DTNB and ASXL2 genes. The fusion of the DTNB and ASXL2 genes has been associated with Breast Invasive Carcinoma, Stomach Adenocarcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DTNB-ASXL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-RERE | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-REOR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-REGO | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-REGR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-REAQ | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-ORRE | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-OROR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-ORGO | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GORE | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GOOR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GOGO | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GOGR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GRRE | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GROR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GRGO | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GRGR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-AQRE | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-AQOR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-AQGO | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-AQGR | 20 (40 μL) | 200 μL |
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| DTNB-ASXL2-20-AQAQ | 20 (40 μL) | 200 μL |
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DTNB Gene Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Gene Name: Dystrobrevin Beta
Chromosome: CHR2: 25600111 -25896503
Locus: 2p23.3
ASXL2 Gene Summary
This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017]
Gene Name: Additional Sex Combs Like 2, Transcriptional Regulator
Chromosome: CHR2: 25962252 -26101312
Locus: 2p23.3
Gene Diseases
The DTNB ASXL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Stomach Adenocarcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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