DUS2L-HSD11B2 Fusion FISH Probe
The DUS2L-HSD11B2 Fusion FISH Probe is used to confirm a fusion of the DUS2L and HSD11B2 genes. The fusion of the DUS2L and HSD11B2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DUS2L-HSD11B2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-RERE | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-REOR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-REGO | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-REGR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-REAQ | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-ORRE | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-OROR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-ORGO | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GORE | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GOOR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GOGO | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GOGR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GRRE | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GROR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GRGO | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GRGR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-AQRE | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-AQOR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-AQGO | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-AQGR | 20 (40 μL) | 200 μL |
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| DUS2L-HSD11B2-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD11B2 Gene Summary
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Gene Name: Hydroxysteroid 11-beta Dehydrogenase 2
Chromosome: CHR16: 67465035 -67471454
Locus: 16q22.1
Gene Diseases
The DUS2L HSD11B2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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