DVL1-OPTN Fusion FISH Probe
The DVL1-OPTN Fusion FISH Probe is used to confirm a fusion of the DVL1 and OPTN genes. The fusion of the DVL1 and OPTN genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DVL1-OPTN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-RERE | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-REOR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-REGO | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-REGR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-REAQ | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-ORRE | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-OROR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-ORGO | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-ORAQ | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GORE | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GOOR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GOGO | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GOGR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GOAQ | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GRRE | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GROR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GRGO | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GRGR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-GRAQ | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-AQRE | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-AQOR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-AQGO | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-AQGR | 20 (40 μL) | 200 μL |
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| DVL1-OPTN-20-AQAQ | 20 (40 μL) | 200 μL |
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DVL1 Gene Summary
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
Gene Name: Dishevelled Segment Polarity Protein 1
Chromosome: CHR1: 1270657 -1284492
Locus: 1p36.33
OPTN Gene Summary
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Optineurin
Chromosome: CHR10: 13142081 -13180276
Locus: 10p13
Gene Diseases
The DVL1 OPTN Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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