DVL1-PLCH2 Fusion FISH Probe
The DVL1-PLCH2 Fusion FISH Probe is used to confirm a fusion of the DVL1 and PLCH2 genes. The fusion of the DVL1 and PLCH2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DVL1-PLCH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-RERE | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-REOR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-REGO | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-REGR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-REAQ | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-ORRE | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-OROR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-ORGO | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GORE | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GOOR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GOGO | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GOGR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GRRE | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GROR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GRGO | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GRGR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-AQRE | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-AQOR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-AQGO | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-AQGR | 20 (40 μL) | 200 μL |
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| DVL1-PLCH2-20-AQAQ | 20 (40 μL) | 200 μL |
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DVL1 Gene Summary
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
Gene Name: Dishevelled Segment Polarity Protein 1
Chromosome: CHR1: 1270657 -1284492
Locus: 1p36.33
PLCH2 Gene Summary
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
Gene Name: Phospholipase C Eta 2
Chromosome: CHR1: 2407753 -2436964
Locus: 1p36.32
Gene Diseases
The DVL1 PLCH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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