DVL2-TFE3 Fusion FISH Probe
The DVL2-TFE3 Fusion FISH Probe is used to confirm a fusion of the DVL2 and TFE3 genes. The fusion of the DVL2 and TFE3 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DVL2-TFE3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-RERE | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-REOR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-REGO | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-REGR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-REAQ | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-ORRE | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-OROR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-ORGO | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-ORAQ | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GORE | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GOOR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GOGO | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GOGR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GOAQ | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GRRE | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GROR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GRGO | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GRGR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-GRAQ | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-AQRE | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-AQOR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-AQGO | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-AQGR | 20 (40 μL) | 200 μL |
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| DVL2-TFE3-20-AQAQ | 20 (40 μL) | 200 μL |
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DVL2 Gene Summary
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Gene Name: Dishevelled Segment Polarity Protein 2
Chromosome: CHR17: 7128660 -7137863
Locus: 17p13.1
TFE3 Gene Summary
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: Transcription Factor Binding To IGHM Enhancer 3
Chromosome: CHRX: 48886241 -48900990
Locus: Xp11.23
Gene Diseases
The DVL2 TFE3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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