DYNC1LI2-NAE1 Fusion FISH Probe
The DYNC1LI2-NAE1 Fusion FISH Probe is used to confirm a fusion of the DYNC1LI2 and NAE1 genes. The fusion of the DYNC1LI2 and NAE1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYNC1LI2-NAE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-RERE | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-REOR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-REGO | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-REGR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-REAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-ORRE | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-OROR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-ORGO | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GORE | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GOOR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GOGO | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GOGR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GRRE | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GROR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GRGO | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GRGR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-AQRE | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-AQOR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-AQGO | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-AQGR | 20 (40 μL) | 200 μL |
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| DYNC1LI2-NAE1-20-AQAQ | 20 (40 μL) | 200 μL |
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DYNC1LI2 Gene Summary
Cytoplasmic dynein is a microtubule-associated motor protein (Hughes et al., 1995 [PubMed 7738094]). See DYNC1H1 (MIM 600112) for general information about dyneins.[supplied by OMIM, Mar 2008]
Gene Name: Dynein Cytoplasmic 1 Light Intermediate Chain 2
Chromosome: CHR16: 66754798 -66785525
Locus: 16q22.1
NAE1 Gene Summary
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NEDD8 Activating Enzyme E1 Subunit 1
Chromosome: CHR16: 66836780 -66864879
Locus: 16q22.1
Gene Diseases
The DYNC1LI2 NAE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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