DYNLL1-COQ5 Fusion FISH Probe
The DYNLL1-COQ5 Fusion FISH Probe is used to confirm a fusion of the DYNLL1 and COQ5 genes. The fusion of the DYNLL1 and COQ5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYNLL1-COQ5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-RERE | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-REOR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-REGO | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-REGR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-REAQ | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-ORRE | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-OROR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-ORGO | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GORE | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GOOR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GOGO | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GOGR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GRRE | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GROR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GRGO | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GRGR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-AQRE | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-AQOR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-AQGO | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-AQGR | 20 (40 μL) | 200 μL |
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| DYNLL1-COQ5-20-AQAQ | 20 (40 μL) | 200 μL |
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DYNLL1 Gene Summary
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Dynein Light Chain LC8-type 1
Chromosome: CHR12: 120907659 -120936298
Locus: 12q24.31
COQ5 Gene Summary
The Coenzyme Q5, Methyltransferase (COQ5) gene is located on chr12 :120941081-120966964 at 12q24.31.
Gene Name: Coenzyme Q5, Methyltransferase
Chromosome: CHR12: 120941081 -120966964
Locus: 12q24.31
Gene Diseases
The DYNLL1 COQ5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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