DYRK1A-KCNJ6 Fusion FISH Probe
The DYRK1A-KCNJ6 Fusion FISH Probe is used to confirm a fusion of the DYRK1A and KCNJ6 genes. The fusion of the DYRK1A and KCNJ6 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| DYRK1A-KCNJ6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-RERE | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-REOR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-REGO | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-REGR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-REAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-ORRE | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-OROR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-ORGO | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-ORAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GORE | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GOOR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GOGO | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GOGR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GOAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GRRE | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GROR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GRGO | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GRGR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-GRAQ | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-AQRE | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-AQOR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-AQGO | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-AQGR | 20 (40 μL) | 200 μL |
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| DYRK1A-KCNJ6-20-AQAQ | 20 (40 μL) | 200 μL |
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DYRK1A Gene Summary
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Chromosome: CHR21: 38739858 -38887679
Locus: 21q22.13
KCNJ6 Gene Summary
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]
Gene Name: Potassium Voltage-gated Channel Subfamily J Member 6
Chromosome: CHR21: 38996785 -39288696
Locus: 21q22.13
Gene Diseases
The DYRK1A KCNJ6 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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