E2F3-FBXO9 Fusion FISH Probe
The E2F3-FBXO9 Fusion FISH Probe is used to confirm a fusion of the E2F3 and FBXO9 genes. The fusion of the E2F3 and FBXO9 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| E2F3-FBXO9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-RERE | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-REOR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-REGO | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-REGR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-REAQ | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-ORRE | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-OROR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-ORGO | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-ORAQ | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GORE | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GOOR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GOGO | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GOGR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GOAQ | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GRRE | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GROR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GRGO | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GRGR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-GRAQ | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-AQRE | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-AQOR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-AQGO | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-AQGR | 20 (40 μL) | 200 μL |
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| E2F3-FBXO9-20-AQAQ | 20 (40 μL) | 200 μL |
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E2F3 Gene Summary
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Name: E2F Transcription Factor 3
Chromosome: CHR6: 20402136 -20493945
Locus: 6p22.3
FBXO9 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein 9
Chromosome: CHR6: 52929795 -52965670
Locus: 6p12.1
Gene Diseases
The E2F3 FBXO9 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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