ELN-FADS2 Fusion FISH Probe
The ELN-FADS2 Fusion FISH Probe is used to confirm a fusion of the ELN and FADS2 genes. The fusion of the ELN and FADS2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELN-FADS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-RERE | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-REOR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-REGO | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-REGR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-REAQ | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-ORRE | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-OROR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-ORGO | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GORE | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GOOR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GOGO | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GOGR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GRRE | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GROR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GRGO | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GRGR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-AQRE | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-AQOR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-AQGO | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-AQGR | 20 (40 μL) | 200 μL |
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| ELN-FADS2-20-AQAQ | 20 (40 μL) | 200 μL |
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ELN Gene Summary
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]
Gene Name: Elastin
Chromosome: CHR7: 73442426 -73484236
Locus: 7q11.23
FADS2 Gene Summary
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Name: Fatty Acid Desaturase 2
Chromosome: CHR11: 61595712 -61634825
Locus: 11q12.2
Gene Diseases
The ELN FADS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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