ELOVL5-PFKFB3 Fusion FISH Probe
The ELOVL5-PFKFB3 Fusion FISH Probe is used to confirm a fusion of the ELOVL5 and PFKFB3 genes. The fusion of the ELOVL5 and PFKFB3 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ELOVL5-PFKFB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-RERE | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-REOR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-REGO | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-REGR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-REAQ | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-ORRE | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-OROR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-ORGO | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GORE | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GOOR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GOGO | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GOGR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GRRE | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GROR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GRGO | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GRGR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-AQRE | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-AQOR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-AQGO | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-AQGR | 20 (40 μL) | 200 μL |
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| ELOVL5-PFKFB3-20-AQAQ | 20 (40 μL) | 200 μL |
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PFKFB3 Gene Summary
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Chromosome: CHR10: 6186842 -6277507
Locus: 10p15.1
ELOVL5 Gene Summary
This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Name: ELOVL Fatty Acid Elongase 5
Chromosome: CHR6: 53132195 -53213977
Locus: 6p12.1
Gene Diseases
The ELOVL5 PFKFB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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