EML1-FBLN5 Fusion FISH Probe
The EML1-FBLN5 Fusion FISH Probe is used to confirm a fusion of the EML1 and FBLN5 genes. The fusion of the EML1 and FBLN5 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| EML1-FBLN5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-RERE | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-REOR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-REGO | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-REGR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-REAQ | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-ORRE | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-OROR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-ORGO | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-ORAQ | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GORE | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GOOR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GOGO | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GOGR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GOAQ | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GRRE | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GROR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GRGO | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GRGR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-GRAQ | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-AQRE | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-AQOR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-AQGO | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-AQGR | 20 (40 μL) | 200 μL |
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| EML1-FBLN5-20-AQAQ | 20 (40 μL) | 200 μL |
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EML1 Gene Summary
Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Echinoderm Microtubule Associated Protein Like 1
Chromosome: CHR14: 100259744 -100408395
Locus: 14q32.2
FBLN5 Gene Summary
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
Gene Name: Fibulin 5
Chromosome: CHR14: 92335754 -92414046
Locus: 14q32.12
Gene Diseases
The EML1 FBLN5 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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