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EML1-TTLL5 Fusion FISH Probe

The EML1-TTLL5 Fusion FISH Probe is used to confirm a fusion of the EML1 and TTLL5 genes. The fusion of the EML1 and TTLL5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
EML1-TTLL5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
EML1-TTLL5-20-RERE 20 (40 μL) 200 μL
EML1-TTLL5-20-REOR 20 (40 μL) 200 μL
EML1-TTLL5-20-REGO 20 (40 μL) 200 μL
EML1-TTLL5-20-REGR 20 (40 μL) 200 μL
EML1-TTLL5-20-REAQ 20 (40 μL) 200 μL
EML1-TTLL5-20-ORRE 20 (40 μL) 200 μL
EML1-TTLL5-20-OROR 20 (40 μL) 200 μL
EML1-TTLL5-20-ORGO 20 (40 μL) 200 μL
EML1-TTLL5-20-ORAQ 20 (40 μL) 200 μL
EML1-TTLL5-20-GORE 20 (40 μL) 200 μL
EML1-TTLL5-20-GOOR 20 (40 μL) 200 μL
EML1-TTLL5-20-GOGO 20 (40 μL) 200 μL
EML1-TTLL5-20-GOGR 20 (40 μL) 200 μL
EML1-TTLL5-20-GOAQ 20 (40 μL) 200 μL
EML1-TTLL5-20-GRRE 20 (40 μL) 200 μL
EML1-TTLL5-20-GROR 20 (40 μL) 200 μL
EML1-TTLL5-20-GRGO 20 (40 μL) 200 μL
EML1-TTLL5-20-GRGR 20 (40 μL) 200 μL
EML1-TTLL5-20-GRAQ 20 (40 μL) 200 μL
EML1-TTLL5-20-AQRE 20 (40 μL) 200 μL
EML1-TTLL5-20-AQOR 20 (40 μL) 200 μL
EML1-TTLL5-20-AQGO 20 (40 μL) 200 μL
EML1-TTLL5-20-AQGR 20 (40 μL) 200 μL
EML1-TTLL5-20-AQAQ 20 (40 μL) 200 μL

EML1 Gene Summary

Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene. Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type. The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems. The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3). The type I is the most severe form. Gene loci responsible for these three types are all mapped. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Echinoderm Microtubule Associated Protein Like 1

Chromosome: CHR14: 100259744 -100408395

Locus: 14q32.2

TTLL5 Gene Summary

This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]

Gene Name: Tubulin Tyrosine Ligase Like 5

Chromosome: CHR14: 76127550 -76421425

Locus: 14q24.3

Gene Diseases

The EML1 TTLL5 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.